文章信息/Info

Title:

Influence of Geometric Structural Parameters of Magnetic Patches on the Uniform Adsorption of Magnetic Particles

文章編號:

1674-3962(2025)12-1135-09

作者:

裴寧; 董耀誠; 龔永勇; 白逸凡; 沈運麗

1. 上海大學理學院，上海 200444 2. 鄭州外國語中學，河南 鄭州 450006 3. 同濟大學 上海東方醫(yī)院，醫(yī)學院心內科，上海 200092

Author(s):

PEI Ning; DONG Yaocheng; GONG Yongyong; BAI Yifan; SHEN Yunli

1. School of Science, Shanghai University, Shanghai 200444, China 2. Zhengzhou Foreign Language Middle School, Zhengzhou 450006, China 3. Department of Cardiology, Shanghai East Hospital, Tongji University, Shanghai 200092, China

關鍵詞:

磁性生物貼片; 磁性顆粒; 磁靶向; 數值仿真; 均勻性吸附

Keywords:

magnetic biological patch;  magnetic particles;  magnetic targeting;  numerical simulation;  uniform adsorption

分類號:

TQ46

DOI:

10.7502/j.issn.1674-3962.202404008

文獻標志碼:

A

摘要:

在磁靶向治療中,磁性粒子的非均勻分布會增大局部組織微循環(huán)栓塞的風險。研究了磁性生物貼片(ferromagnetic biological patch, MBP)的幾何參數對貼片吸附磁性微粒的均勻性的影響。利用數值仿真方法，研究了MBP局域磁場的磁通密度及其梯度隨MBP幾何參數和外磁場強度的變化規(guī)律。MBP的聚磁作用隨著貼片厚度T的增加、外磁場B0的增強、距離H的減小而增強。通過在貼片中心設置空氣孔，當空氣孔孔徑（略小于臨界直徑Db0）和間距合適時，可以使孔之間形成磁通密度極大值，使貼片中間、孔中心和貼片邊緣都能吸附較多微粒。MBP中心空氣孔孔徑為0��40 mm時能夠較均勻地吸附磁性微球，與仿真結果相吻合。

Abstract:

In magnetic drug targeting therapy, the non�瞮niform distribution of magnetic particles can elevate the risk of local tissue microcirculation embolism. This study employed a ferromagnetic biological patch (MBP) to explore the influence of the geometric parameters of the MBP on the uniformity of magnetic microparticle adsorption. The effects of geometric parameters of the MBP and the magnetic flux density of external magnetic field（MF）on the local inhomogeneous MF around the MBP were investigated based on numerical simulation．The magnetic concentrating effect of the MBP is enhanced with the increase in the patch thickness T and the augmentation of the external MF B0 and the decrease in the distance H from the patch. By setting bores at the center of the patch, when the bores diameter (slightly smaller than the critical diameter Db0) and the spacing are appropriate, the maximum magnetic flux density can be formed between the bores, and both the center and the edge of the patch, as well as the center of pores, can adsorb magnetic particles uniformly. The MBP with a central bore diameter of 0.40 mm can adsorb magnetic microspheres in a relatively uniform manner, which is aligned with the simulation results.