文章信息/Info

Title:

Medical Tissue Adhesives: Research Progress

文章編號:

1674-3962(2020)07-0535-16

作者:

朱浩方1; 2; 毛宏理1; 2; 顧忠偉1; 2

（1. 南京工業(yè)大學(xué)材料科學(xué)與工程學(xué)院，江蘇 南京 211816）（2. 南京工業(yè)大學(xué)新材料研究院 生物材料研究所，江蘇 南京 211816）

Author(s):

ZHU Haofang1; 2;  MAO Hongli1; 2;  GU Zhongwei1; 2

(1. College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, China) (2. Research Institute for Biomaterials, Tech Institute for Advanced Materials, Nanjing Tech University, Nanjing 211816, China)

關(guān)鍵詞:

醫(yī)用軟組織粘合劑; 商業(yè)化醫(yī)用粘合劑; 研究進展; 臨床轉(zhuǎn)化

Keywords:

soft tissue adhesive;  commercial tissue adhesive;  research progress;  clinical translation

分類號:

R318.08

DOI:

10.7502/j.issn.1674-3962.202006028

文獻標志碼:

A

摘要:

醫(yī)用組織粘合劑因其具有操作簡便、無創(chuàng)粘合、即時密封和止血作用、可有效縮短手術(shù)時間等顯著優(yōu)勢，獲得了醫(yī)療領(lǐng)域的廣泛關(guān)注，并逐漸成為傳統(tǒng)手術(shù)縫合線的有效輔助或替代手段。目前，已有多種基于各類材料的商業(yè)化醫(yī)用組織粘合劑被批準用于心臟、血管、肺等軟組織的修復(fù)再生。然而，現(xiàn)有的大多數(shù)市售醫(yī)用組織粘合劑仍然面臨著粘合強度不夠、功能單一、原料昂貴、生物相容性欠佳、安全隱患等挑戰(zhàn)，臨床上對于開發(fā)新型高效的多功能軟組織粘合劑的需求極為迫切。在簡要介紹各類軟組織粘合劑的研究現(xiàn)狀和粘合機制的基礎(chǔ)上，對當前醫(yī)用軟組織粘合劑的研究熱點、面臨挑戰(zhàn)及其臨床轉(zhuǎn)化應(yīng)用情況進行了闡述，最后提出了未來的研究重點和發(fā)展趨勢。

Abstract:

Medical tissue adhesives have gained wide attention because of their obvious advantages over conventional sutures such as easy operation, non�瞚nvasive sealing, and immediate hemostasis. At present, a variety of commercial medical tissue adhesives based on various materials have been developed to replace or assist sutures in the application of repair and regeneration of heart, blood vessels, lungs and other soft tissues. However, existing tissue adhesives are usually either cytotoxic, fragile, or lacking adhesive strength. Therefore, significant research endeavors have been focused on developing a safe and effective tissue adhesive to overcome these problems. In this review, we firstly introduce the basic research status and adhesion mechanism of various types of tissue adhesives. Then the current hotspots and recent progress of medical tissue adhesives, as well as their clinical translation applications are summarized in detail. Finally, the future research direction and the prospect of tissue adhesives are proposed.