文章信息/Info

Title:

Intelligent Hydrogels and Their Applications in Biological Fields

作者:

劉程; 喬麗媛; 柳承德; 楊力全; 蹇錫高

（大連理工大學(xué)化工學(xué)院 高分子材料系，遼寧 大連 116024）

Author(s):

LIU Cheng;  QIAO Liyuan;  LIU Chengde;  YANG Liquan;  JIAN Xigao

(Department of Polymer Materials, College of Chemical Engineering, Dalian University of Technology, Dalian 116024, China)

關(guān)鍵詞:

溫敏性; pH響應(yīng)性; 自修復(fù)性; 藥物載體; 細(xì)胞負(fù)載與傳遞; 傷口敷料

Keywords:

temperature sensitivity;  pH responsiveness;  self�瞙ealing property;  drug delivery;  cell loading and delivery;  wound dressing

DOI:

10.7502/j.issn.1674-3962.201906001

文獻(xiàn)標(biāo)志碼:

A

摘要:

水凝膠含水量極高、質(zhì)地柔軟且具有優(yōu)異的生物相容性。其中，智能水凝膠因其優(yōu)異的環(huán)境響應(yīng)性而備受關(guān)注。近年來(lái)，各類(lèi)智能水凝膠層出不窮，其機(jī)械強(qiáng)度從數(shù)十帕變化到數(shù)十兆帕，在生物醫(yī)學(xué)領(lǐng)域的應(yīng)用包括藥物載體、組織工程支架等�；�于此，詳細(xì)總結(jié)了近年來(lái)智能水凝膠的發(fā)展及應(yīng)用。首先，依據(jù)不同的分類(lèi)方式對(duì)水凝膠進(jìn)行了分類(lèi)。進(jìn)一步，重點(diǎn)對(duì)智能水凝膠進(jìn)行了詳細(xì)的分類(lèi)，包括溫敏性水凝膠、pH響應(yīng)性水凝膠、自修復(fù)水凝膠等，同時(shí)對(duì)每類(lèi)智能水凝膠的制備及應(yīng)用進(jìn)行了詳細(xì)的介紹。最后，概述了智能水凝膠在生物方向的應(yīng)用，包括藥物載體、細(xì)胞負(fù)載與傳遞、傷口敷料等。

Abstract:

Hydrogels, with high water content, have soft texture and excellent biocompatibility. Among them, intelligent hydrogels have attracted much attention due to their excellent environmental responsiveness. The intelligent hydrogels emerge in endlessly in recent years, the mechanical strength of intelligent hydrogels changes from tens of Pa to tens of MPa, and they can be applied in biomedicine including drug carriers, tissue engineering scaffolds, etc. Based on this, this paper summarizes the development and applications of intelligent hydrogels in recent years. Firstly, hydrogels can be classified into different types according to different classification methods. Furthermore, this paper mainly summarizes different types of intelligent hydrogels, including temperature sensitive hydrogels, pH responsive hydrogels and self-healing hydrogels, also elaborates and analyzes the experimental cases of each kind of intelligent hydrogels in detail. Finally, the applications of various intelligent hydrogels in biological fields are summarized, including drug delivery, cell loading and delivery, wound dressing, etc.