文章信息/Info

Title:

Element Selection of Medical Magnesium Alloys from the Perspective of Degradable Metals

文章編號(hào):

1674-3962(2020)02-0092-08

作者:

鄭玉峰1; 2; 劉嘉寧2

（1. 北京大學(xué)工學(xué)院 材料科學(xué)與工程系，北京 100871）（2. 北京大學(xué)前沿交叉學(xué)科研究院 生物醫(yī)學(xué)跨學(xué)科中心，北京 100871）

Author(s):

ZHENG Yufeng1; 2;  LIU Jianing2

(1. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China) (2. BioMed�瞂 Center, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China)

關(guān)鍵詞:

降解金屬; 醫(yī)用鎂合金; 生物降解性; 生物相容性; 合金設(shè)計(jì)

Keywords:

biodegradable metal;  biomedical magnesium alloy;  biodegradability;  biocompatibility;  alloy design

分類號(hào):

R318.08

DOI:

10.7502/j.issn.1674-3962.201907012

文獻(xiàn)標(biāo)志碼:

A

摘要:

進(jìn)入21世紀(jì)以來，可降解金屬成為醫(yī)用金屬材料研究的熱點(diǎn)。鎂及鎂合金是過去10余年被廣泛研究的代表性可降解金屬材料。Web of Science 檢索顯示，過去10余年有關(guān)醫(yī)用鎂合金的基礎(chǔ)研究工作在全球范圍內(nèi)已經(jīng)發(fā)表了3000余篇文章，人們對(duì)可降解鎂合金與機(jī)體的力學(xué)、化學(xué)和生物學(xué)相互作用機(jī)制有了較深入的認(rèn)識(shí)，初步開展了“醫(yī)用鎂合金的成分設(shè)計(jì)與性能優(yōu)化”、“鎂合金在體內(nèi)的降解機(jī)制及其調(diào)控方法”、“鎂合金降解產(chǎn)物的生物安全性與代謝途徑”、“鎂合金降解過程中的力學(xué)強(qiáng)度退化”等基礎(chǔ)科學(xué)研究。盡管已有大量的新配方鎂合金被設(shè)計(jì)與研究用于生物醫(yī)學(xué)，但多為工程材料專家們的炒菜式思維，企業(yè)對(duì)投入費(fèi)時(shí)費(fèi)錢的生物醫(yī)學(xué)驗(yàn)證坐等，醫(yī)學(xué)轉(zhuǎn)化成效低。在成百上千的已有材料配方中，迄今在全球上市的醫(yī)用鎂合金植入式醫(yī)療器械只有德國WE43系鎂合金和韓國Mg-Ca-Zn合金，國內(nèi)進(jìn)入創(chuàng)新醫(yī)療器械的兩個(gè)產(chǎn)品是以純鎂為材料。因此，擬從生物材料專家的視角出發(fā)，摒棄對(duì)力學(xué)性能的追求，從可降解金屬的生物降解性和生物安全性兩個(gè)最基本的判據(jù)出發(fā)，對(duì)元素周期表中適合可降解金屬的元素進(jìn)行初步篩選，在此基礎(chǔ)上選出用于醫(yī)用鎂合金的合金化元素，換一個(gè)角度，從更佳的生物學(xué)性能和生物功能性出發(fā)，對(duì)未來醫(yī)用鎂合金材料設(shè)計(jì)指明可以嘗試的新方向。

Abstract:

Since the beginning of the 21st century, biodegradable metals have become a hot spot in the field of metallic biomaterials. Magnesium and its alloys are representative biodegradable metals that have been studied over the past decade. According to the search results of Web of Science, more than three thousand SCI articles have been published on the basic research work in the past ten years. With depth�瞮nderstanding of interaction mechanisms between degradable magnesium alloys and mechanics, chemistry and biology of host, some basic scientific problems have been preliminarily studied, such as “the composition design and performance optimization of biomedical magnesium alloys”, “the degradation mechanism of magnesium alloy in vivo and its regulation methods”, “the biosafety and metabolic pathways of degradation product of magnesium alloys” and “the degeneration of mechanical properties during the degradation process of magnesium alloys”, etc. Although a large number of magnesium alloys have been designed and studied for biomedical applications, they did not seem to be satisfactory for the medical device companies. Until now, there are only two magnesium alloys used as implanted medical devices that marketed worldwide—the WE43 series alloy from Germany, and Mg-Zn-Ca alloys from South Korea. Currently two products that have entered the innovative medical device in China are made of high purity magnesium. Therefore, in this paper, the preliminary screening of elements which are suitable for degradable metals in the periodic table are made by dual criteria: biodegradability and biocompatibility. On this basis, the promising alloying elements for biomedical magnesium alloys are proposed. It is supposed to provide a new direction for the material design of future medical magnesium alloys from a different perspective, with better biosafety and biofunction.