文章信息/Info

Title:

Magnetic Nanoparticles for Labelling and Functional Regulation of Mesenchymal Stem Cells

作者:

馬思雨1; 2; 王鵬1; 3; 楊玉志2; 孫劍飛1; 4; 顧寧1; 4

1. 東南大學(xué)生物科學(xué)與醫(yī)學(xué)工程學(xué)院 江蘇省生物材料與器件重點實驗室 生物電子學(xué)國家重點實驗室
2. 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院 臨床醫(yī)學(xué)工程處
3. 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院 運動醫(yī)學(xué)與成人重建外科
4. 蘇州納米科技協(xié)同創(chuàng)新中心

Author(s):

MA Siyu1; 2; WANG Peng1; 3; YANG Yuzhi2; SUN Jianfei1; 4; GU Ning1; 4

1. Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioeletronics, School of Biological Sciences & Medical Engineering, Southeast University
2. Clinical Medical Engineering Office, Nanjing Drum Tower Hospital of Nanjing University Medical School
3. Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School
4. Collaborative Innovation Center of Suzhou Nano-Science and Technology

關(guān)鍵詞:

磁性納米顆粒; 間充質(zhì)干細胞; 組織修復(fù); 標(biāo)記

Keywords:

magnetic nanoparticles;  mesenchymal stem cells;  tissue repair;  label

DOI:

10.7502/j.issn.1674-3962.201811020

文獻標(biāo)志碼:

A

摘要:

干細胞治療是目前組織修復(fù)領(lǐng)域中最有潛力的治療方法，但由于缺乏有效的干細胞示蹤技術(shù)等原因，目前的多數(shù)研究都還停留在實驗階段。需要利用干細胞體內(nèi)示蹤技術(shù)對移植到體內(nèi)后干細胞的分布、活性、分化、凋亡情況進行檢測。因此，干細胞示蹤技術(shù)的發(fā)展對解決上述問題起到了至關(guān)重要的作用。目前，磁性納米顆粒標(biāo)記干細胞后，利用磁共振成像技（magnetic resonance imaging, MRI）有望實現(xiàn)體外無創(chuàng)、實時、安全、有效的長期示蹤觀察。對間充質(zhì)干細胞的組織修復(fù)原理、磁性納米顆粒參與協(xié)助間充質(zhì)干細胞的組織修復(fù)以及磁性納米顆粒標(biāo)記干細胞的技術(shù)進行了系統(tǒng)綜述。

Abstract:

Stem cell therapy is the most promising treatment in the field of tissue repair. However, vast majority of current investigations still remain in the stage of laboratory. It is of great significance to detect the distribution, activity, differentiation and apoptosis of stem cells after transplantation by in-vivo tracing technique. Therefore, the development of the techniques for tracing stem cells has played a crucial role in solving these problems. Nowadays, magnetic resonance imaging (MRI) has been used to explore long-term in-vitro tracing of magnetic nanoparticles labeled stem cells. Furthermore, it is noninvasive, real-time, safe and effective. The principle of mesenchymal stem cells (MSCs) for tissue repair was systematically summarized. Also, the labeling and assistance effect of magnetic nanoparticles on MSCs for tissue repair were reviewed.