文章信息/Info

Title:

Bone Regeneration Mechanism of Advanced Biomaterials for Hard Tissue Repair

作者:

鄒學(xué)農(nóng); 陳大福; 田偉; 張西正; 吳剛; 董華; 周永勝; 周光前

（1.中山大學(xué)附屬第一醫(yī)院骨科研究所，廣東 廣州 510080)��
(2.北京積水潭醫(yī)院創(chuàng)傷骨科研究所，北京 100035)��
(3.中國(guó)人民解放軍軍事醫(yī)學(xué)科學(xué)院衛(wèi)生裝備研究所，天津 300161)��
(4.華南理工大學(xué)國(guó)家人體組織功能重建工程技術(shù)研究中心，廣東 廣州 510006)��

Author(s):

 ZOU Xuenong ; CHEN Dafu;  TIAN Wei;  ZHANG Xizheng;  WU Gang;  DONG Hua;  ZHOU Yongsheng;  ZHOU Guangqian

 1. Orthopaedic Research Institute, First Affiliated Hospital of Sun Yat�瞫en University, Guangzhou 510080, China）��

關(guān)鍵詞:

硬組織修復(fù)材料; 骨再生; 宿主防御; 宿主微環(huán)境; 表觀遺傳學(xué); 基因調(diào)控

DOI:

10.7502/j.issn.1674-3962.2012.09.06

文獻(xiàn)標(biāo)志碼:

A

摘要:

傳統(tǒng)硬組織修復(fù)材料由于在組成及結(jié)構(gòu)上與人體骨組織存在較大差異，植入體內(nèi)后的骨組織修復(fù)過(guò)程基本上是一種被動(dòng)的“充填”過(guò)程，且材料的降解速度與新骨形成速度不匹配，難以達(dá)到真正的“生物性融合”，嚴(yán)重制約了該類(lèi)材料在骨科臨床的推廣應(yīng)用。因此，設(shè)計(jì)與制備具有“主動(dòng)修復(fù)功能”和“可調(diào)控生物響應(yīng)特性”的第3代新型硬組織修復(fù)材料已成為當(dāng)前骨科臨床的新需求和未來(lái)的發(fā)展方向。介紹了硬組織修復(fù)材料的骨再生機(jī)理研究方法，綜述了硬組織修復(fù)材料與宿主防御和骨再生及宿主微環(huán)境對(duì)材料與宿主細(xì)胞相互作用的研究現(xiàn)狀。指出硬組織修復(fù)材料植入體內(nèi)后所發(fā)生的序列事件可能通過(guò)表觀遺傳修飾使得基因表達(dá)受材料本身和宿主微環(huán)境等因素的調(diào)控，提出新型硬組織修復(fù)材料研究中存在的問(wèn)題和發(fā)展趨勢(shì)。��

Abstract:

Traditional biomaterials for hard tissue repair in composition and structure are hugely different with human bone tissue. The repairing process of these materials is basically a passive “filling” process when implanted in the body. Because new bone formation and material degradation rate do not match well enough, it is difficult to achieve the real “biological fusion”, and this restricted the use of materials in orthopaedic clinical application. Therefore, design and preparation of advanced third generation biomaterials for hard tissue repair with “active repair function” and “controlled biological response characteristics” has become the new demand of orthopaedic clinical application and future research direction. This paper introduced main research methods for bone regeneration mechanisms of advanced biomaterials for hard tissue repair, and it also summarized the current research results of interactions between these biomaterials and host cells in host microenvironment, and interactions between the biomaterials and host defense responses in the process of bone regeneration.