[1]陳昌盛,李仕穎,王俊,等.小分子硼酸肽的自組裝[J].中國材料進(jìn)展,2012,(6):049-54.[doi:10.7502/j.issn.1674-3962.2012.06.08]
CHEN Changsheng,LI Shiying,WANG Jun,et al.Self-Assembly of Oligo-Borono-Peptides[J].MATERIALS CHINA,2012,(6):049-54.[doi:10.7502/j.issn.1674-3962.2012.06.08]
點(diǎn)擊復(fù)制
小分子硼酸肽的自組裝(
)
中國材料進(jìn)展[ISSN:1674-3962/CN:61-1473/TG]
- 卷:
-
- 期數(shù):
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2012年第6期
- 頁碼:
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049-54
- 欄目:
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特約研究論文
- 出版日期:
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2012-06-25
文章信息/Info
- Title:
-
Self-Assembly of Oligo-Borono-Peptides
- 作者:
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陳昌盛; 李仕穎; 王俊; 張先正; 卓仁禧
-
（武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院 生物醫(yī)用高分子材料教育部重點(diǎn)實(shí)驗(yàn)室，湖北 武漢 430072）
- Author(s):
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CHEN Changsheng; LI Shiying; WANG Jun; ZHANG Xianzheng; ZHUO Renxi
-
（Key Laboratory of Biomedical Polymers of Education Ministry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China）
-
- 關(guān)鍵詞:
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硼酸肽; 自組裝; 超分子聚集體; 納米材料
- DOI:
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10.7502/j.issn.1674-3962.2012.06.08
- 文獻(xiàn)標(biāo)志碼:
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A
- 摘要:
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利用FMOC化學(xué)固相多肽合成法合成了3種含精氨酸的小分子硼酸肽（標(biāo)記為BPs（13））。在生理pH下，含陽離子的硼酸肽可自組裝形成有序超分子納米組裝體。二羥基酚染料茜素紅與硼酸肽可特異性結(jié)合形成五元環(huán)硼酸酯，伴隨熒光和顏色的顯著變化，可進(jìn)一步調(diào)控硼酸肽的自組裝行為。通過掃描電鏡研究茜素紅調(diào)控前后硼酸肽的自組裝形態(tài)，并用紅外光譜和圓二色譜研究其自組裝機(jī)理。結(jié)果表明，3種含精氨酸硼酸肽在生理pH下可自組裝形成不同的超分子納米組裝體。通過茜素紅的調(diào)控，茜素紅/硼酸肽化合物，可自組裝形成更有序，更精致的超分子聚集體。
- Abstract:
-
Three arginine containing oligo borono peptides (BPs(1 3)) were synthesized by employing a standard FMOC chemistry SPPS. BPs(13) could spontaneously selfassemble into supramolecular architectures at a physiological environment. With recognition between BPs and alizarin red S (ARS), the fivemembered ring borate esters (ARS/BPs) could be formed with dramatic changes in fluorescent feature and visible color. These selfassembled supramolecular architectures were observed by scanning electron microscope (SEM) and their selfassembly mechanisms were explored by Fourier Transform Infrared Spectroscopy (FTIR) and Circular Dichroism (CD). It was found that BPs were capable of selfassembling into wellordered supramolecular architectures, and after recognition of ARS, ARS/BPs could further selfassemble into more ordered and sophisticated supramolecular architectures.
更新日期/Last Update:
2012-07-26