文章信息/Info

Title:

Design and Challenge of Nanotheranostic Agent

作者:

柯亨特; 梁曉龍; 戴志飛

（1.哈爾濱工業(yè)大學(xué)納米醫(yī)藥與生物傳感器實(shí)驗(yàn)室，黑龍江 哈爾濱 150080）
（2.北京大學(xué)工學(xué)院生物醫(yī)學(xué)工程系，北京 100871）

Author(s):

KE Hengte����1��; LIANG Xiaolong����2��;  DAI Zhifei����1;  2

(1.Nanomedicine and Biosensor Laboratory, Harbin Institute of Technology, Harbin 150080, China)��
(2.Department of Biomedical Engineering, Peking University, Beijing 100871, China)

關(guān)鍵詞:

診療制劑; 診斷; 治療; 納米粒子

DOI:

10.7502/j.issn.1674-3962.2012.06.03

文獻(xiàn)標(biāo)志碼:

A

摘要:

癌癥是一種具有高度異質(zhì)性和極強(qiáng)適應(yīng)性的疾病，需要根據(jù)病人的特點(diǎn)和疾病的進(jìn)展選擇不同類型的診斷和治療方案。診療時(shí)聯(lián)用納米制劑能為患者提供各種個(gè)性化的診斷治療方案，從而改善治療效果。因此，研發(fā)新型多功能納米診療制劑具有重要的意義。介紹了當(dāng)前常用的診斷制劑和適用的治療方法，診斷制劑包括X射線計(jì)算機(jī)斷層掃描造影劑、超聲造影劑、磁共振造影劑以及正電子發(fā)射斷層掃描造影劑等，治療方法包括化療、放療、光動(dòng)力治療、光熱治療以及基因治療等。綜述了近年來文獻(xiàn)報(bào)道的各種典型的納米診療制劑，并提出了診療制劑研究中存在的問題和今后可能的發(fā)展方向。

Abstract:

Cancer is a highly heterogeneous and adaptable disease, therefore, diverse types of treatment options need to be chosen depending on patient characteristics and disease progression. Theranostic nanoparticles provide patients with various treatment options that are suitable for individuals, and thereby result in improved prognosis. So it is important to develop novel multifunctional nano�瞭heranostic agents. Commonly used diagnostic agents and treatment methods were introduced, such as diagnostic agents including X�瞨ay computed tomography contrast agents, ultrasound contrast agents, MRI contrast agents and positron emission tomography imaging agents. Treatment methods include chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy and gene therapy. A variety of typical nano�瞭heranostic agents reported in recent years were reviewed, and the problems existed in the studies of theranostics and the possibly future development direction were also proposed.