[1]李玉莉,陳曉峰,韓雪,等.微納米生物玻璃的體外成骨性能研究[J].中國材料進展,2012,(6):007-11.[doi:10.7502/j.issn.1674-3962.2012.06.02]
LI Yuli,CHEN Xiaofeng,HAN Xue,et al. Biocompatibility and Osteogenesis of Micro and Nano Bioactive Glasses[J].MATERIALS CHINA,2012,(6):007-11.[doi:10.7502/j.issn.1674-3962.2012.06.02]
點擊復制
微納米生物玻璃的體外成骨性能研究(
)
中國材料進展[ISSN:1674-3962/CN:61-1473/TG]
- 卷:
-
- 期數(shù):
-
2012年第6期
- 頁碼:
-
007-11
- 欄目:
-
前沿綜述
- 出版日期:
-
2012-06-25
文章信息/Info
- Title:
-
Biocompatibility and Osteogenesis of Micro and Nano Bioactive Glasses
- 作者:
-
李玉莉; 陳曉峰; 韓雪; 苗國厚; 胡慶; 雷波
-
(1.華南理工大學材料科學與工程學院, 廣東 廣州 510640)
(2.國家人體組織功能重建工程技術(shù)研究中心, 廣東 廣州 510006)
(3.廣東省生物醫(yī)學工程重點實驗室, 廣東 廣州 510006)
- Author(s):
-
LI Yuli1; 2; 3; CHEN Xiaofeng1; 2; 3; HAN Xue1; 2; 3; MIAO Guohou1; 2; 3; HU Qing1; 2; 3; LEI Bo1; 2; 3
-
(1.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China)
(2.National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China)
(3.Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China)
-
- 關(guān)鍵詞:
-
微納米生物玻璃; 溶膠-凝膠技術(shù); 堿性磷酸酶; 成骨基因
- DOI:
-
10.7502/j.issn.1674-3962.2012.06.02
- 文獻標志碼:
-
A
- 摘要:
-
微納米生物活性玻璃因其具有特殊的形態(tài)結(jié)構(gòu)和理化性能目前引起眾多研究者的關(guān)注，但是目前對微納米生物活性玻璃的結(jié)構(gòu)及形態(tài)對細胞性能的影響研究的較少。本文通過溶膠-凝膠法結(jié)合模板仿生技術(shù)合成了具有特殊結(jié)構(gòu)和形態(tài)的微納米生物活性玻璃，并通過體外細胞實驗，研究了這種微納米結(jié)構(gòu)對人骨髓間充質(zhì)干細胞成骨性能（ALP, Runx2, Col1a1 和OPN）的影響，結(jié)果證明具有規(guī)則形態(tài)的生物活性玻璃（SBG）相比不規(guī)則形態(tài)的生物活性玻璃（IBG）更能促進細胞的體外成骨性能，為將來設(shè)計具有特定結(jié)構(gòu)的生物活性玻璃提供了參考依據(jù)。
- Abstract:
-
Because of the special morphology and characterization, micro and nano bioactive glass caused much attention by researchers, but the morphology of micro and nano bioactive glass on cell performance has been underappreciated and underinvestigated. The special morphology of micro and nano bioactive glass was synthesized by the Sol gel method combined with the template bionic. Human mesenchymal stem cells (hMSCs) were seeded on bioactive glass for 6 days and 10 days in vitro for alkalic phosphatase (ALP) activity and 5days for osteogenic gene expression analysis. Based on the results of ALP activity and osteogenic gene expression analysis, the responses of hMSCs to the SBG exhibited a higher degree of osteogenic differentiation than those on IBG in vitro. This work will provide a reference for design of specific morphology of the bioactive glass in the future.
更新日期/Last Update:
2012-07-26