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Title:: Biocompatibility and Gene activation of Micro/Nano-Bioactive Glasses

Author(s):: Hu Qing1; 2; 3; Chen xiaofeng1; 2; 3*; Dong yanmei4; Gong weiyu4; (1 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, P.R China) (2 National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China) (3 Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China) (4 Peking university school of stomatology, Beijing 100081, China)

Abstract:: Micro/nano biological material has become the research hotspot and difficulty in the field of biomedical materials. A number of studies have shown that micro/nano structure of biological material can show a positive biological response. Bioactive glass (BG) has the high apatite-forming bioactivity and biocompatibility. BG is the ideal biomaterial for bone tissue regeneration. Micro/nano-bioactive glass (MNBG) caused much attention because of the special morphology and physicochemical properties, but the research about MNBG only focused on preparation and the in vitro apatite-forming bioactivity, few papers have focused on the biocompatibility and gene activation. This study used sol-gel method combining biological organic templates to design micro/nano structure of bioactive glasses. The effects of MNBG and traditional melt 45S5 ionic dissolution products on proliferation, expression of osteogenic genes, proteins were investigated. The results showed that MNBG promoted cell-proliferation, up-regulated the expression of osteogenic genes and proteins. This work will provide a reference for design of specific morphology of the bioactive bone repair materials in the future